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KMID : 1004820090100030099
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Journal of Biomedical Research
2009 Volume.10 No. 3 p.99 ~ p.108
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Promoting Effect of Herbal Extracts Mixtures on Hair Regrowth in C3H/HeJ Mice
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Kim Jong-Soo
Kang Bong-Su
Park Hyun-Ji
Kim Dang-Young
Hwang Seon-Young
Nam Sang-Yoon
Yun Young-Won
Lee Beom-Jun
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Abstract
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Although hair disorders are not life threatening, a lot of people who suffer hair loss and/or hairthinning is increasing in accordance with changes in lifestyle and nutritional balance. The aim of this study was to examine the effects of herbal extracts on hair regrowth in C3H/HeJ mice. There were 6 experimental groups including distilled water (D.W.), 50% ethanol (a vehicle control), 3% minoxidil (a positive control), and 3 kinds of herbal extracts mixtures (C, D & E). The test compounds included followings; C : Glycyrrhizae radix, Rhei Rhizoma, Cornus officinalis and Sesami semeni, D : Viticus fructus, Pulsatilla chinensis, Gardenia fructus and Artemisiae argyi herb, E : Swertia pseudo-chinensis, Sophora flavescens Scutellaria baicalensis and Salvia miltiorrhiza. The animals were shaved with an electric clipper. The testcompounds were daily treated to dorsal skin with 0.2 ml per mouse for 3 weeks. The topical application of the E test solution accelerated hair regrowth after 10 days faster than that of the positive and vehicle controls. The activities of alkaline phosphatase (ALP) and γ-glutamyl transpeptidase significantly were increased inall the treatment groups after 3 weeks, compared with D.W. group. Especially, the E test solution notably increased ALP activity compared with positive or vehicle control group. Epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were increased in all the treatment groups after 3 weeks comparedwith D.W. group. These results suggest that the herbal extracts have hair regrowth effect by increasing enzyme activities and growth factors and it can be useful for treatment for alopecia in humans.
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KEYWORD
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Hair growth, Minoxidil, Herbal extract, Alopecia
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